Week 3 kickoff features Bills vs. Dolphins as the marquee opener, with two high-powered offenses expected to push the pace and fantasy scores. The 16-game slate centers on division battles, star matchups, and injury news that will shape start/sit calls and DFS lineups throughout the weekend.

Tools and projections from PFF guide the edge battles, run defenses, and pass-blocking duels that fantasy managers chase. Expect tight ends and backfields to factor in strong ways as teams navigate a short week and pivotal early-season tests.

Rams host Eagles in a high-stakes playoff rematch, powered by Stafford’s accuracy and Puka Nacua’s breakout as the offense gains a timely edge. LA’s improved protection keeps the ceiling high and gives fantasy managers a reason to chase a big day from Stafford and his rising target.

From the power-rankings lens, Los Angeles sits as a rising NFC contender, while Philadelphia remains a top-tier test. A Rams win could tilt the NFC narrative and push LA further into the elite, making complementary football on both sides of the ball essential for success.